Markets & Economy Article · 5 min read
Warren Buffett, 96, stepped down Friday as chairman of Berkshire Hathaway, a title he'd held since 1970, handing it to his son Howard while Greg Abel keeps running the company day to day. The job change is mostly a formality eight months after Buffett already gave up the CEO seat. The advice he leav
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Health Article · 5 min read
What is ataxia-telangiectasia, and does the drug the FDA just approved for it actually work? A-T is a rare, inherited disorder in a DNA-repair gene that causes progressive loss of coordination starting in early childhood. On September 18, 2026, the FDA approved levacetylleucine (Aqneursa) as the fir
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The World Article · 3 min read
11 stories across Business & markets, Bitcoin & crypto, Technology, Science, World, Health & medicine, tracked on September 19, 2026.
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Computers & Gadgets Article · 3 min read
Apple's new Mac Studio ships September 22 with M5 Max and M5 Ultra chips, up to 512GB of unified memory, and the same 7.7-inch-square case it's shipped since 2023. I've always liked Apple machines, and I was expecting a smaller redesign — it isn't one, and the real story turns out to be better than
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Space Article · 3 min read
The James Webb Space Telescope's newest, largest public image is a panorama of a stellar nursery called IC 348 — and buried in it are the smallest brown dwarfs ever confirmed, weighing in at about twice the mass of Jupiter. That number is smaller than the theory of how stars form says it should be a
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Food & Cooking Article · 6 min read
National Cheeseburger Day, a Vancouver, Washington location that ran out of buns, lettuce, and pickles by six, and a two-hour wait made bearable by free peanuts and better company than expected — plus where this one lands against In-N-Out and Habit.
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The World Article · 2 min read
12 stories across Macro & markets, Bitcoin & crypto, Technology, Science, World, Arts & culture, tracked on September 18, 2026.
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Health Article · 10 min read
Three weeks after approving daraxonrasib for pancreatic cancer that has already been treated — the first drug to roughly double survival in that disease — the FDA gave it Breakthrough Therapy status for newly diagnosed patients, on top of chemotherapy. What the drug does, what the trials actually sh
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Markets & Economy Article · 10 min read
My friend sent a screenshot of the XRP rich list and a thought: only 8.13 million XRP accounts exist, so "less than 1 percent of 1 percent" of humanity owns any, and yet the coin gets endless attention. Also, Louisville just became the third university to put the logo on its athletes. He's right abo
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Markets & Economy Article · 12 min read
The same friend who has kept this week's entries honest sent two more texts tonight — three Ripple links, a line about how "AI and crypto will merge," and a theory involving Elon Musk's favorite letter and a 2 percent stake Stripe took in 2014. I read all three announcements. He's right that the pip
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Markets & Economy Article · 13 min read
A post went around this week saying Zcash at $1,200 is Bitcoin at $1,200 — study 2017. The arithmetic behind it is genuinely correct, which is the most interesting thing about it and the reason it's worth taking apart. Here is what the post is actually claiming, why the supply math works, why the co
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Ethics Article · 7 min read
A bed net costs about $6 and lasts three years, which makes malaria prevention a subscription with 600 million subscribers and no end date. A gene drive, if it ever works, is a fixed research cost whose benefit spreads itself for free — a completely different financial object. Global malaria funding
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Policy Article · 11 min read
The same morning the SEC gave tokenized stocks a five-year exemption, the CFTC's staff quietly did something with a longer shelf life and a smaller signature: a seven-page letter saying any app that routes orders to a registered exchange, holds none of the money, and takes a cut of every trade doesn
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Markets & Economy Article · 10 min read
Yesterday I wrote that the SEC and CFTC would build crypto rules without Congress. This morning the same friend who started that conversation texted me the SEC's "Innovation Exemption" with two words of commentary — "the genie" — and a five-year number. He's right about the number. Here's what the o
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Biology Article · 9 min read
Malaria killed about 610,000 people in 2024, three quarters of them children under five. One approach to ending it does not spray anything, distribute anything, or ask anyone to take a pill — it edits the mosquito so the parasite cannot survive inside it, and lets the edit spread itself through the
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The World Article · 2 min read
13 stories across Macro & markets, Bitcoin & crypto, Artificial intelligence, Science, World, Health & medicine, tracked on September 17, 2026.
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The World Article · 9 min read
Ursula von der Leyen's 2026 State of the Union names a war on the continent, a closed Strait of Hormuz that has cost Europe €90 billion, a €1-billion-a-day trade deficit with China and a Russian drone attack in Leipzig — and the two proposals that leave the hall with a date attached are a Heatwave P
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Health Article · 12 min read
On September 14 the FDA approved Bexlutry, Curium's copy of Novartis's Lutathera — the first "radioligand equivalent" ever cleared. The question underneath the headline: what is a radioligand therapy, what does the evidence say it does for neuroendocrine tumours, and why did it take a Delaware court
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Policy Article · 6 min read
A friend forwarded me a tweet the morning after the CLARITY Act's cloture vote failed — a former CFTC chairman saying the current SEC and CFTC chiefs will build crypto rules with or without Congress. It reads like a hypothetical. It isn't. Both agencies have been building exactly that framework in p
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Markets & Economy Article · 5 min read
The Fed hiked a quarter point on Wednesday, 12 to 0 — unanimous, from a committee that voted 9 to 3 to hold in July. Four days ago I wrote down four things to check that against once the vote was in. Here is what actually happened to each one.
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